The track recently topped the US chart, earning Lovato her very first number one single.
Speaking to MTV News, Lovato said she is happy to know that such a personal song resonated with her fans.
"The reception for my single is so amazing," she said. "It's been going up the charts for a while now and right now I actually have my first No.1 single, so that's really exciting for me. It means so much to me."
The singer continued: "I never thought I'd be blessed enough to have this opportunity and here I am. It's just so incredible."
Lovato's love life recently made headlines when she was teased by her fellow X Factor USA judge Simon Cowell about her reported romance with One Direction's Niall Horan.
She said of the dating rumours: "I'm not looking for anything. I'm not going to date anybody for a whole year. And I made that clear to him."
The X Factor USA's second season premieres Wednesday (September 12) on Fox.
Watch Demi Lovato's 'Give Your Heart a Break' music video below: