The Maroon 5 frontman will join other featured artists on the album, including Kanye West, Lil Wayne, Nicki Minaj, John Legend, Meek Mill and Pusha T.
Game - whose real name is Jayceon Terrell Taylor - told Rolling Stone: "When everybody hears the Adam Levine record, I think they gonna go crazy."
"I want that to hit people in the face," he added. "It's a real dope record."
Jesus Piece is a follow-up to Game's 2011 longplayer The R.E.D. Album.
Levine recently signed Tony Lucca to his label 222 Records. Lucca was a contestant on The Voice, where he was part of Levine's team.
Watch the music video for Maroon 5's 'Payphone' below: