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Over three million Lego bricks have been delivered to Denbies Wine Estate in Dorking, where the TV star will develop a two-storey property.
Members of the public can help with the project on a building day organised for this Saturday.
"I've got a man working on a flushing Lego lavatory. We think it's possible," he told the BBC.
"Things like power supply, sanitation and plumbing coming into the house are as they could be for a real building... everything within my Lego house must as far as possible be Lego," he said.
May is building the house as part of his new TV show James May's Toy Stories. The presenter's other projects have included building a garden out of plasticine and making the world's largest model plane.
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