In charge of the protection of Britain's historical sites, the National Trust aims to attract younger members with tales of the area's lurid past.
The audio guide will be a "no-holds barred" tour around the infamous back streets, where sex, violence and wild partying were normal.
'Soho Stories' will tell the history of the red light district in a "vivid way", but only to those over the age of 17.
Story highlights include a phone box that was a cover-up for a crack den and tales of artist Francis Bacon being whipped.
London director of the Trust Ivo Dawnay said: "British rock-and-roll, feminism and gay liberation were all born in Soho, and this new technology allows us to deliver those stories in a vivid way.
"Some of the language is a little close to the bone and it may not suit all members, but we have a strong health warning on the packaging."
The app is free to use and tourists will be guided by GPS around the Soho area.
> Woman has "perfect" job as sex toy tester
> Chinese TV reporter mistakes male sex toy for rare mushroom - video