The colossal food fight takes place every year in the small town of Bunol, near Valencia, on the last Wednesday of August.
Metro reports that around 40,000 people from all over the world descended on the town, which normally holds just 10,000 inhabitants.
The festival has been held in Bunol every year since 1945.
Rafael Perez, a town spokesman said: "We don't have much space, but there is no other way".
A week-long festival featuring music, parades, dancing, and fireworks precedes the famous tomato fight. On the penultimate night, those participating in La Tomatina hold a paella cooking contest.
La Tomatina featured prominently in last year's British film We Need To Talk About Kevin, where Tilda Swinton's character took part in the festival.
After La Tomatina concludes, the village's streets are hosed down and quickly return to pristine condition, due to the acidity of the tomatoes acting as a disinfectant.