Domestos has backed Andrew Shoben's artwork, which is positioned between Tower Bridge and City Hall to mark World Toilet Day (November 19) and will remain in Potters Field Park until November 21.
Members of the public can upload their photos or a five-second video - via the Public Toilet website - to be screened on the face of the sculpture.
World Toilet Day aims to raise awareness of much of the world's poor sanitation, which contributes to the deaths of 801,000 children every year from diarrhoea.
A survey to mark the event revealed that 71% of people would be put off by a potential partner's bad toilet habits, while 60% would wait at least two months before going to the loo in a new partner's house.
Meanwhile, 31% of people use tablets, smartphones and ebooks on the toilet and 40% admit using the toilet cubicle to work.
Domestos's ambassador and World Toilet Day etiquette expert Kim Woodburn said: "This survey shows how our toilet etiquette is really going down the drain and whilst it's good to stay in touch with friends using the latest gizmos, not everyone wants to see your toilet face!
"Whilst we can use the toilet to escape in-laws or send tweets, 1.1 billion people suffer the humiliation of not being able to go in private."