The X Factor boss will join the likes of Osama bin Laden, Saddam Hussein and Muammar Gaddafi as potential targets at Machine Guns Vegas.
A spokesman for Machine Guns Vegas stated: "We agree with Martin Gore from Depeche Mode that Simon Cowell has committed heinous crimes against humanity, and single-handedly demolished real musical talent across the planet.
"The Cowell target is expected to become a popular target - ranking up there with Osama bin Laden."
Controversially, Depeche Mode's Martin Gore has previously said that Cowell "should be shot".
Cowell took to Twitter to respond to Gore, writing: "Why I am angry about weirdo gore is a ton of people have got shot this year and people.like weirdo gore encourage this."
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