The pair - and their partners Stacy Keibler and Rande Gerber - star in a new advertisement for Clooney and Gerber's new tequila brand Casamigos.
[Left: Clooney and Crawford / Right: Gerber]
The video was written and produced by Clooney.
The advert has the caption, 'It could happen, please drink responsibly', and initially shows Gerber walking in to find his wife in bed with Clooney.
As the advert continues Clooney, to his delight, then finds Keibler and Crawford under the sheets.
The funny video, used to highlight the importance of drinking alcohol responsibly, ends with the two women finding Clooney and Gerber in bed together, much to Clooney's surprise.
Watch Clooney and Crawford in the video below: