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Cruise famously appeared on Winfrey's chat show to declare his love for his fiancee, but the couple have not included the presenter in their guest list.
Winfrey said: "It's not that I'm not going. It's that they had a limited number of people that they could invite. I was not one of the invitees. That's fine. I don't get invited to everyone's wedding. I don't invite them to everything I do. But I wish them the best".
Winfrey added that she still held the couple in high regard, and would be buying a gift for the ceremony: "I have a great deal of regard for their relationship and so I'm trying to think of what to get them."
Cruise and Holmes are currently in Italy preparing for their marriage.
