Murphy plays the two lead roles in the children's sci-fi adventure, but chose not to attend the screening in LA on Tuesday.
The actor is currently working on comedy drama A Thousand Words with director Brian Robbins.
"He's not here because he's doing a movie and shooting - he goes back-to-back-to-back," producer David T. Friendly told People.
"Eddie, he'll never admit it, but he loves to work. And I think work keeps him happy."
Meet Dave opens in the UK on July 18.