Showbiz
Rex Features
The singer never recovered from her split from Penn in 1989 after four years of marriage, according to Christopher Ciccone.
Speaking to Extra to promote his tell-all memoir Life With My Sister Madonna, he said: "Sean was definitely the love of her life."
He added that he and Penn had a close friendship, saying: "He cut my thumb open - he cut his open - we pressed them together and he was like, 'OK, cool - now we're blood brothers!'"
The TV chef, who is estranged from Madonna, previously blamed her current husband Guy Ritchie for the breakdown of their relationship.
> Beatty 'searched Madonna's rubbish'
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