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The 39-year-old told USA Today that she is tired of fielding questions about her on-off relationship with rock star John Mayer.
"I think it's ridiculous. There's just this insatiable need," she commented.
"I am honestly getting sick of it, and I feel like telling people, 'You know what? It's none of your f**king business'. Seriously, it's enough."
Aniston said that she hopes her new film, canine comedy Marley & Me, will swing discussion away from her personal life.
"I haven't had a movie in a long time, so hopefully this is going to create something else to talk about and realise that I have a job, and I'm an actress," she explained.
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