According to The Sun, Katona walked out of her family home in Wilmslow, Cheshire, on Thursday with two life coaches in tow.
Since then, the reality TV star's nanny has also been spotted leaving the house, taking the couple's one-year-old son Max with her.
Katona's marriage previously hit the rocks in March, with the former I'm A Celebrity… winner announcing that she was planning a divorce. However, the pair reunited days later.
They had also parted ways temporarily in February following a row over their two-year wedding anniversary.
Katona already has one failed marriage after her relationship with Brian McFadden broke down in 2004. The Irish singer is now engaged to Australian star Delta Goodrem.