The former Playboy model, whose partner is The Truman Show actor Jim Carrey, said that she thinks that Jesus Christ would be a great boyfriend if he wasn't "dead".
McCarthy wrote on her Twitter page: "I'm looking at a picture of Jesus on the wall. I would have totally dated Jesus. Love that beard. Too bad he's dead."
Some of the star's followers on the social networking site then took offence to this, McCarthy wrote: "Okay, Okay my friends. I know Jesus is not dead. I'm saying that the fact his body has 'risen from the dead' makes him un-datable."
Later that day, McCarthy tweeted: "Did they do circumcisions in Jesus days?"