The Whip It! director/actress, who marched to protest when the California Supreme Court voted to uphold Proposition 8 last year, will be presented with the 'Vanguard Award' for being an outspoken supporter of gay rights, In Touch Weekly reports.
Barrymore said: "I was born, bred and raised among diversity, it has defined me and made me the person I am today. I'm honoured and humbled to be receiving this award."
Comedian and talkshow host Wanda Sykes is also being honoured with the 'Stephen F. Kolzak Award'.
The ceremony will be held in Los Angeles on April 17.