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Ashley has been accused of cheating on Cheryl with up to five women since their marriage in 2006.
A spokesman for the star said: "Cheryl Cole is separating from her husband Ashley Cole.
"Cheryl asks the media to respect her privacy during this difficult time. We have no further comment to make."
It was claimed earlier this week that Cheryl broke up with Ashley via a text message.
> Cole 'to announce divorce within weeks'
