The Giuliana and Bill stars have been trying to get pregnant for over a year. Rancic appeared on Thursday's episode of The View to publicly discuss the procedure.
"A lot of these women get IVF, and they just don't talk about it," Rancic said. "And listen, celebrities are entitled to their privacy. I'm not saying 'shame on you for not talking about it.' But if we can talk about it and let women know that it's okay, look at all your options."
Rancic, 35, cited her age as the primary obstacle in becoming pregnant, though her doctor suggested that it may be her weight.
"He said five to ten pounds, which I know isn't a big deal and if you want to have a baby you should do whatever it takes... I finally did gain the five pounds. We're working on more."
The couple's struggle with fertility has been a frequent topic of discussion on their show, which airs Sunday nights on the Style and E! networks.