Ayurvedic tablets, which are a traditional Indian therapy, have been sent to Madonna, who already has two children, eight-year-old daughter Lourdes, and four-year-old son, Rocco.
A source told the newspaper, "Tablets were sent over from India for her. They looked like horse tablets - they were just so huge. The pills are supposed to increase potency."
The 46-year-old singer has also visited the clinic of celebrity obstetrician Dr Gowri Motha, who was recommended to Madonna by Gwyneth Paltrow.
"It's no secret she wants another baby," a friend explained. "She has talked about it. Having children has transformed her life and she really wants to have a big family.
"She and Guy are very happy together and their friends are hoping she gets pregnant again."