In an appearance on ESPN's The BS Report, the comic claimed that Aniston is a "masculine" woman that men find threatening.
"I don't think she repels men," he explained.
"I think she probably has a lot of testosterone and probably thinks like a man... There are certain women out there, they say you can tell from the jaw line... they did some study that women who have sharp jaw lines... it's a masculine feature."
Carolla went on to compare the actress's dating approach to that of her Bounty Hunter co-star Gerard Butler.
"The point is, maybe she has a little too much testosterone and maybe she is a female version of one of these guys who bangs his way through Hollywood.
"Like a female Gerard Butler."