The 37-year-old actress and reality TV star, who has two children with husband Dean McDermott, appeared alongside stars such as Tiffani Thiessen, Jennie Garth, Luke Perry and Shannen Doherty in the '90s US teen drama.
Talking about Thiessen, Spelling told Ryan Seacrest: "She doesn't talk to me anymore." She then admitted that she is in touch with Garth.
"All my cast members hate me," she added. "We were great friends during 90210. We were friends after 90210. They all came to my first wedding. All of a sudden I marry Dean, and I don't know what happened. I lost all my cast members."