The rapper, who was recently detained in a sex assault claim, told MTV News that Wayne has detoxed from drugs and alcohol while in prison and is now in "great spirits".
"I love Lil Wayne; that's like my little brother," he said.
"He's just the coolest dude on Earth. I tell you one thing, him not being high made me realise how much funnier he is. This guy has jokes. We were up in there for four hours, just telling jokes, dying laughing, falling on the floor."
He added that the public should try to look past Wayne's criminal activity and appreciate who he is as a person.
"He's a beautiful dude. He did what he did. He had a gun on him, but people don't really know how much of a great father that he is, great of a person he is, a friend, a loyal dude. He's charismatic," he explained.
"It's just sad to see him over there like that, but I'm pretty sure he learned his lesson, and he's gonna be focused."
Wayne is currently serving a one-year sentence for gun possession at Riker's Island in New York.