The vampire romance took home gongs for 'Choice Movie: Fantasy' and 'Choice: Summer Movie', while stars Kristen Stewart (Bella Swan), Robert Pattinson (Edward Cullen) and Taylor Lautner (Jacob) were each honoured with individual acting awards.
Stewart and Pattinson also scooped trophies for 'Choice: Liplock' and 'Choice: Chemistry', while co-stars Ashley Greene (Alice Cullen) and Kellan Lutz (Emmett Cullen) were named 'Choice: Scene Stealers' and Rachelle Lefevre (Victoria) was awarded 'Choice: Villain'.
More than 85 million votes were cast in this year's ceremony, which also saw Avatar, The Last Song and Valentine's Day among the movie victors. Individual winners included Sandra Bullock, Leonardo DiCaprio and Megan Fox, while Pattinson also picked up acting honours for Remember Me.
In the television categories, Vampire Diaries, Gossip Girl and Glee were victorious, while American Idol and Keeping Up With The Kardashians triumphed in the reality television fields.
Elsewhere, Justin Bieber, Lady GaGa and Paramore took home prizes in the music categories, which also saw honours handed out for Eminem, Taylor Swift and Selena Gomez & The Scene. David Beckham was named 'Choice Athlete: Male', while Serena Williams took 'Choice Athlete: Female'. Lautner and Fox were also recognised as this year's 'Choice Hotties'.
The Teen Choice Awards 2010, hosted by Katy Perry, airs tonight at 8pm ET/PT on Fox.