Kennedy, who played Curly Watts in the ITV1 soap, will take on the role of Pop as the Queen-themed show enters its tenth year.
The former soap star will appear in the musical from September, following his success in the same part on last year's touring production around the UK.
Joining Kennedy in the cast are X Factor's Brenda Edwards, who will play Killer Queen, Ricardo Afonso as Galileo, Rachel John as Meat and Sarah French as Scaramouche.
Bookings are now being taken for We Will Rock You at the Dominion Theatre untill April 2011.
> Curly and Reg to reunite in Corrie DVD