The actress told Harper's Bazaar that she she admires and respects her Going The Distance co-star.
"He's the cat's pajamas," she said. "I couldn't love, respect, admire and enjoy that individual more than I do."
The star continued: "It would be physically impossible for me to have any more giggly joy at this person."
Barrymore added that while she enjoys romance, she has reached a stage in her life where she is also comfortable being single.
"I'm really good on my own… I was good in my early teens, and then I got really bad at being alone for like 10 years.
"And then for the last decade I've developed such a love of my independence that I have to go, 'Okay, you've had dinner by yourself three nights in a row, now you have to see your friends'."
Going The Distance is now playing in US cinemas.