The couple were appearing on Ryan Seacrest's KIIS-FM show to promote their relationship book I Do, Now What? when Seacrest asked them what had been the hardest part of married life.
"I gotta be honest Ryan, as you are single and not married, it's actually pretty awesome if you marry the right person," replied Giuliana.
"I married my best friend. Bill and I really are best friends first and foremost; we have the best time. The hardest thing is probably not being together all the time. Everything else is pretty darn easy, I'm not going to kid you!"
The couple also reflected on their decision to share news of their recent miscarriage with the public. "We were both pretty reluctant in the beginning but in hindsight I'm glad we did," said Bill. "So many people have come forward and thanked us for being brave and showing this because it happens to, I think, one in four couples in America but no-one talks about it."
Giuliana and Bill recently suggested that they are ready to try for a baby again, saying that they are "optimistic" that 2011 could be the year they become parents.
I Do, Now What? is available now. Giuliana & Bill continues on the Style Network this Monday.