The comedian told Metro that he did not see the point of the social networking website.
Lock said: "I know loads of people who do it and I don't understand it. It's a medium for comedians to get rid of shoddy, half-baked ideas that wouldn't make it into a comedy set. It seems like it's for sad, needy people who should have a word with themselves."
Asked if he was tempted to sign up to see how many followers he could amass, he continued: "There's something very macho about that - about how many followers you have. Jesus had followers but he had something important to say, not, 'Had a bath, watched Sex And The City'. It's not healthy.
"All these people who are receiving your messages - sitting at bus stops, or at home with the family - they're not engaged with the world, they're checking their f**king phone and you're just adding to that white noise of bulls**t."
Lock added: "There's someone on Twitter who pretends to be me but as long as he doesn't say anything damaging, I don't care. Let him get on with it."