According to TMZ, the couple, who were married for 17 years, separated in September. Ann cited "irreconcilable differences" as the reason behind the split.
They have a 14-year-old daughter, Mayan, together. Ann is seeking primary physical custody of Mayan as well as spousal support.
The pair apparently had no prenuptial agreement.
George's rep said of the split in September: "George and Ann Lopez have made the decision to end their 17-year marriage. The decision is amicable and by mutual agreement.
"They remain dedicated parents, and committed partners in business and their philanthropic organisation The Lopez Foundation."