The couple - who recently revealed that they suffered a miscarriage earlier this year - said that they are now open to options such as adoption and surrogacy to ensure they are able to raise a child.
"Whether we can have kids or not have kids, I think we're open to everything," Giuliana told People.
"And whether we adopt or use a surrogate, or have our own natural child, I think at the end of the day, the most important thing is you have a baby, and it's a baby you're going to shower with love."
Bill also praised his wife's courage during the aftermath of losing a child.
"She was so stoic and brave, and she never complained about any of the shots or anything we had to go through," he recalled.
"This experience has given me a new perspective on my wife."