The Sex And The City actress will be recognised for her preservation work with and activism for African elephants, which are often targeted by ivory hunters, reports PopEater.
"Kristin Davis is the embodiment of the Wyler Award," said HSUS senior director Beverly Kaskey.
"Known for her compassion for all animals, Kristin has made elephants a primary cause, and we are proud to acknowledge her work spreading the message about a critical animal issue."
Davis said in a statement: "I am so excited to receive the Wyler Award from The Humane Society of the United States, as it gives me the opportunity to keep talking about an issue that's a profound labour of love for me.
"Elephants are truly amazing animals and they need our protection, and what people in this country may not realise is that they can help by not buying ivory items."
She will receive the Wyler Award at the Genesis Awards to be held in Hollywood on March 19.