Earlier this month, the former Two and a Half Men star insisted that having two live-in girlfriends was a perfect fit for his lifestyle.
While appearing on The Joy Behar Show, Silverman quipped that she is "honoured" that Sheen follows her on social networking website Twitter but would not consider moving into his LA-area mansion.
"I'm probably not his type," she joked.
The comic continued: "I know he's totally sober, but whether he is or not, I don't like that coke-y energy… I'm a stoner. I like slow and chilled and let's watch TV."
The star also went on to express her belief that the media frenzy surrounding Sheen's personal life has reached a "plateau" because more serious crises have begun to grab headlines.
Silverman recently described her nude scene in director Sarah Polley's upcoming film Take This Waltz as "not sexual".