US Weekly reports that the Bridget Jones actress, who was rumoured to have split from Cooper earlier this month, was spotted removing her belongings out of the Pacific Palisades estate on Thursday afternoon.
"She seems to be handling the break-up well. She had a big smile on her face and a skip in her step!" a source told the publication.
"Her friends feel bad it ended, but Renée's okay. She tried to make it work, but in the end it was too hard."
Zellweger is said to have recently visited Sandra Bullock in New York City to seek solace from the break-up.
It was also suggested that Cooper's burgeoning career was the reason behind the split.