The couple first met on the set of Mamma Mia!, and were in a long-distance relationship for two years before splitting up last summer.
In an interview with The Daily Telegraph, Seyfried said that she is "not apprehensive" about the possibility of seeing Cooper during her trip to London, where she is promoting her new film Red Riding Hood.
"It's going to be a good trip and I'm not apprehensive about going back," revealed Seyfried. "I miss it so much, and anyway, [Dominic]'s not going to be there. He's away shooting, although we are very much in touch."
Seyfried has previously admitted that she misses Cooper since they broke up, although she has recently been linked to actor Ryan Phillippe.
Red Riding Hood hits UK cinemas on April 15.