Morrison, who stars on Glee as Will Schuester, spoke to The Billy Bush Show about the infestation, saying that his house is covered in rat feces.
"I came home and World War III broke out in my house," he said. "There was rat poop all over my house when I got home. I go upstairs [and] there was a huge rat in my bed. And like, poop and feces all over my bed."
Morrison went on to explain that he is now considering selling the house due to the horrifying experience.
"This is my house that I own. Now I want to put it back on the market!" he said.
The actor recently spoke about his character on Glee, revealing that he loves Will's faults, particularly after his divorce from Terri (Jessalyn Gilsig).
Glee airs Tuesdays at 8pm in the US on Fox and Mondays at 9pm on E4 in the UK.