The former Dancing with the Stars contestant and daughter of former vice-presidential candidate Sarah Palin will head the untitled programme along with Kyle and Christopher Massey.
The show will follow Bristol's move to Los Angeles with son Tripp as well as her work with a small charity organisation in the area and her day-to-day experiences while with the Massey brothers.
"Bristol is the kind of personality BIO is drawn to," said A&E and BIO Executive Vice President of Programming David McKillop.
"Her personal life has been playing out in the media for several years but this will be the first time she's opening up her real life, with her son and her friends the Massey Brothers."
The ten-part, half-hour series will be produced by Associated Television International and will air on the BIO Channel later this year.
Palin recently announced plans to write a tell-all memoir entitled Not Afraid of Life, which will provide readers with an "intimate behind-the-scenes look at her life".