A spokesperson confirmed to the New York Post's Page Six column that the Austin Powers comic and his new wife Kelly Tisdale are expecting their first child, due to arrive later this year.
The couple married in a "beautiful" 2010 ceremony, but Myers only revealed details of their secret nuptials in March.
Myers and Tisdale are believed to have started dating in 2006, just months after the Shrek star split with his wife of 12 years Robin Ruzan.
Myers recently described his life and career as "a dream" come true.
He said of his success: "A lot of it was very hard work... but a lot of it is unbelievable luck. For this, I'm very grateful."