The stand-up comedian and actor, who will perform his first UK show in 13 years at the London venue on June 3, told Sky News that he feels excited that his success has reached beyond the United States.
"I even feel funny saying this, but the truth of the matter is, I feel like this is a very big marking point in my career," he explained.
"I was thrilled for the success that I had, on the TV show, but to have reached that far, that I have that many fans in another country, in another culture... this is kind of the biggest thing in my career."
Seinfeld also commented on the price of tickets for the show. The £100 cost had attracted criticism from fans when the performance was originally announced last December.
"I really haven't been involved in that part of the marketing, but I apologise if I made a problem," he continued.
"If you can't afford to come to the show, I will let you in," he also quipped.
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