The former Ugly Betty actress announced to Latina magazine that she will give birth to a son later this year.
"We know it's a boy! [We] are trying to come up with some names that we can agree on," she told the publication.
"It has to be Spanish, but something non-speakers can pronounce without mauling. Suggestions? I'm open."
The couple are already parents to a 23-month-old daughter, Paloma Louise.
Ortiz, who recently signed on for a three-episode story arc on Hung, added that the pregnancy would not be written into the show and that they are instead "shooting around it".