The former Nanny actress, who along with Jacobson recently signed a deal with TV Land to write and produce a full season of their new sitcom Happily Divorced, told People that the series is largely true to life and reflects the former couple's real relationship.
"During our marriage he had told me he might be bisexual, but he wanted to stay married. By the time he told me [that he's gay] I had survived uterine cancer. Nothing could shake me," Drescher explained.
"It's great that we had the ability and the wisdom to reinvent our relationship. All those years weren't for nothing. We're very tight. We're best friends."
Drescher and Jacobson met while attending Hillcrest High School in Jamaica, Queens. They married in 1978 and divorced in 1999. They have no children.
Happily Divorced, which also stars Rita Moreno, Tischina Arnold and Robert Walden, will premiere on June 15.