The Mock The Week star will present sets from Al Murray, Lucy Porter, Dan Antipolski and Simon Evans at the fundraiser for New Horizon Youth Centre on July 18.
Byrne said: "It's incredible that in Central London, one of the world's richest cities, there are so many homeless young people facing such bleak futures.
"It's heart-breaking to know that sleeping rough, lack of opportunities to train for work, access to basic facilities like a shower, laundry and food are issues that persist for so many people on our doorstep."
He added: "This performance will be a great chance to see some of Britain's most talented comics for a knock-down price and I urge each and every one of you to get a ticket and have a laugh while helping to support those on your doorstep who need it most."
Tickets are priced between £20 and £35 and are available now.
New Horizon Youth Centre works with up to 3,000 young people a year and offers vulnerable people drugs advice, tenancy support services, food, showers, clothes, laundry facilities, education programmes and accommodation support.
Watch Ed Byrne talk about marriage on BBC's Live at the Apollo below: