The helmer withdrew from the troubled musical in March. It is now being directed by The Boy from Oz's Philip William McKinley.
She told the Los Angeles Times: "It's incredibly difficult to be under a shot-glass and a microscope like that."
Taymor added that she had disliked the use of focus teams to make artistic decisions on the musical, saying: "There's always something people don't like."
The director won Tony Awards for directing and costume design on previous Broadway musical The Lion King, of which she said she wanted to create a show where "audiences should be able to hook in at many different levels".
"But if The Lion King had been audience-tested and pre-screened in advance, there would be no death of Mustafa (Simba's father) and there would've been no Swahili, Zulu or Xhosa in the show," she added.
Bono, who scored the production with U2 bandmate The Edge, recently said that he had disagreed with Taymor's vision, but was "disappointed" about her departure.
Watch Bono and The Edge preview Spider-Man: Turn Off the Dark on American Idol below: