The '4 Minutes' singer, who adopted son David and daughter Mercy from the impoverished South African country, explained her charitable goals in an interview for Ovation's new series American Revolutionaries: The Hitmakers.
Madonna explained: "My short term goals are to build an orphan care centre that will service and reach at least 1,000 children and I'm also actively involved in funding several orphanages that already exist."
It was reported in March that Madonna's charity Raising Malawi had squandered more than £2.4 million ($3.8m) over plans for a school that was never built, leading to an upheaval in the foundation's board of directors.
Madonna was later said to be considering taking legal action against the directors following the financial mismanagement.
She revealed in January 2011 that she planned to restructure Raising Malawi so that the charity could operate on a "bigger scale" in the coming years.