The Horrible Bosses actress is said to be forgoing further film roles in favour of concentrating on the development of her prison singing movie The Goree Girls, which she will both star in and produce.
Aniston will reportedly begin the break following the October release of her upcoming comedy film Wanderlust alongside Paul Rudd.
"Jen's taking a year off from work to enjoy herself," a source told US Weekly of Aniston's decision.
The insider also claimed that Aniston would recruit rumoured boyfriend Justin Theroux to work on The Goree Girls as she is "impressed by his ability to find humour in dry material".
Aniston recently insisted that she is "very lucky" and "very happy" in her personal life.
The Friends star was announced as a recipient of her own star on the Hollywood Walk of Fame last month.
Watch the trailer for Horrible Bosses below: