The E! News host revealed that she will undergo in vitro fertilization once again in the near future, according to E! Online.
"We're definitely going to do IVF again in the near future," Giuliana said. "If it doesn't work, that will have been three times - but I think third time's a charm. I feel good about the third time!"
Giuliana claimed that she and BIll were no longer actively trying to conceive a child together earlier this month.
The pair have undergone IVF twice previously, first in March 2010 and then in November 2010. The couple announced that they had suffered a miscarriage in October of last year.
Last year, Giuliana insisted that she and husband Bill will become parents in the future in spite of their ongoing struggles with fertility.