Prince, Paris and Blanket appeared with their aunt La Toya at Children's Hospital Los Angeles on Monday for a ceremony to honour Michael.
La Toya said that she hopes her brother's "whimsical" and "magical" art will bring joy to sick children, adding: "You look at [these drawings], it makes you happy."
Michael's hand-drawn sketches of Peter Pan, Mickey Mouse and his own moon-walk dance are among the pictures that will be displayed in the medical centre.
Former Entertainment Tonight host Mary Hart helped to organised the donation.
Watch footage of Monday's unveiling ceremony below:
In June, a life-spanning exhibit called The Michael Jackson Experience opened at Madame Tussauds Hollywood.
'Fill Me In' musician Craig David has announced that he will perform at the Jackson family's tribute to Michael, which will be held in October at Cardiff's Millennium Stadium.
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Watch Michael Jackson perform 'You Are Not Alone' below: