The Parks and Recreation actor told Parade that he enjoys the website's capability of allowing celebrities to "set the record straight immediately" by writing directly to fans.
"I've come to really like Twitter. You really do get to see what I'm about, and I like sharing with my fans. A lot of my fans have been with me - without dating myself - for like three decades, so it's great to be able to reach out to them," Lowe explained.
"It's a great way to set the record straight immediately. I was on a TV show this morning and Donald Trump was on as well and we were having a few laughs and I said, 'Donald, you should get back into the race. You would be so great in a Republican debate,' and then there were immediate headlines that I urged him to run for president.
"So I went to Twitter and said, 'Donald and I were just having fun.' In a previous time, this story becomes 'I called for Donald to run for president'. Now, you can immediately go in and tell people the spirit of the conversation. I like the way you can circumvent the media gatekeepers and go right to the people. That's my favourite thing about Twitter."
Lowe recently confirmed that he will reprise his role as movie star Eddie Nero in the upcoming season of Californication.
He was recently cast alongside Kaley Cuoco in a Lifetime movie about the life of murder suspect Drew Peterson, though Peterson has since filed legal papers to stop production on the project.