The actor admitted that three divorces have soured him on ever walking down the aisle for a fourth time.
"A couple of things I don't do well - marriage and drinking. So I've quit both," Sheen joked to chatshow host Wendy Williams.
He continued: "Why would I [wed again]? That's not to say I couldn't have a substantial relationship one day, but to ordain it with a piece of paper just feels like it makes things worse, just for me personally. Because those relationships, I want to say they were pretty good before the marriage and then something happens."
Sheen also confirmed that he and ex-wife Brooke Mueller have repaired their once-strained relationship and are working together to parent their two sons Bob and Max.
He explained: "We're friends and we're just trying to stay that way and be good parents and just set a good example. We're not back together or anything… [We are living together] off and on, we're not sure what the plan is going to be but we're working all that stuff out."
This week, it was reported that Sheen could receive $25 million (£16 million) from Warner Bros Television if he drops his lawsuit for unfair dismissal from Two and a Half Men.
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Watch Charlie Sheen discuss marriage with Wendy Williams below: