The ceremony, which celebrates the best of sci-fi, fantasy, horror and comic books, will be taped on Saturday, October 15 at Universal Studios in Los Angeles.
Iron Man star Robert Downey Jr will accept the 'Hero Award', while Nicolas Cage will be on hand to receive the Maverick Award to "recognise his fearless and intriguing body of work", as well as premiering exclusive footage from the upcoming film Ghost Rider: Spirit of Vengeance.
Black Swan director Darren Aronofsky, Fringe creator JJ Abrams and Let Me In actress Chloe Moretz have also been confirmed to attend.
Joining them are Harold and Kumar stars Kal Penn and John Cho , True Blood's Joe Manganiello, Doctor Who actor Matt Smith and Fringe's Anna Torv, with more to be announced in the upcoming days.
The broadcast will also feature a special farewell to the Harry Potter franchise as well as premiering new previews from Total Recall, The Woman in Black, Paranormal Activity 3 and Sherlock Holmes: A Game of Shadows.
"The superstars and superheroes who are coming to Scream this year do it because they love and appreciate these fans for their unparalleled passion. We have a lot of Scream-worthy surprises for the fans this year," said executive vice president of event production for Viacom Media Networks Entertainment Group, Casey Patterson.
The two-hour broadcast of the Spike TV Scream Awards 2011 will air Tuesday, October 18 at 9PM ET/PT.