The veteran television broadcaster revealed via Twitter that he will interview Johnny Depp for a special that is due to air on Sunday (October 16).
"Excited to announce my next special: an interview with Johnny Depp! Airs Sunday, 10/16 at 8pmET/5pmPT," King wrote.
He also posted a picture of the two sitting down together.
King previously named Depp as "high on the list" on subjects who he would be keen to interview, Entertainment Weekly reports.
Depp recently issued an apology after comparing being photographed to getting raped, saying that he was "truly sorry for offending anyone in any way".
Last week, the actor claimed that he would be willing to make more Pirates of the Caribbean movies, insisting that his continued involvement in the Disney movies depends on his children.
Larry King's interview with Johnny Depp airs Sunday, October 16 at 8pm on CNN.