The Enlightened star has two kids with musician Ben Harper, who filed for divorce from Dern last October.
Dern explained that she and Harper realised early on in their marriage that they would need to hire a nanny to help out when they're working.
She told USA Today: "God bless nannies. I'm not embarrassed. I read these articles sometimes. It's [bull]. I have a nanny. I did it alone [at first]. Ben was working. My son was born and I wanted to be with my child all the time.
"We still had some help. I took a solid year off. It was perfect. When I went back to work, and now having two and Ben is a touring musician - these women who help us raise our children, who have their own lives, we are all a team."
Dern also revealed that 10-year-old son Ellery and 5-year-old daughter Jaya have already taken an interest in show business.
"My daughter wants to do yoga with me and wants to be in the theatre thing, and I can't tell her, 'Don't be an actress.' My son loves guitar and loves to be in a band and wants his iTunes downloaded with all this old-school hip-hop so he understands where hip-hop came from," she said.
"The time, the effort it takes, to acknowledge their interests! My mum [Diane Ladd] works. My dad [Bruce Dern] works. Ben's mum [Ellen Chase-Verdries] works. My parents are actors with full careers going. It's interesting."
Enlightened airs Mondays at 9.30pm ET on HBO.
Watch a trailer for Enlightened below: