The Modern Family actress and husband Scott Phillips are already parents to 4-year-old son Oliver and 2-year-old twins John and Gus. She said that their family is large enough as it is.
"Immaculate conception is the only way another kid is coming out of me! I love my children, but no mas!" she told US Weekly.
Bowen, who is currently scouting out kindergartens for her son Oliver, also vowed not to become over-involved in his schooling as she has not had positive results in the past.
"I was class mum at the preschool one year and I was pretty much asked not to do that again!" she explained.
"I would set up meetings for all the mums in class and forget to show up - not because I'm a dingbat, but because of schedule changes. It turns out that's a full-time job! I thought class mum made a phone call once a year. No, no, no! It's a daily job!"
Bowen previously confessed that she both loves and hates her kids and becomes frustrated with motherhood on occasion.
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